Periodontitis tied with preeclampsia in pregnant women
Sudy supports a positive association between periodontitis and pregnancy complications.
CHICAGO -- Results of a new study support the hypothesis that chronic
periodontal infection increases the risk of developing preeclampsia in
This study printed in February's issue of the Journal of Periodontology.
The results also suggest that maternal chronic periodontal disease is a risk factor for low birthweight babies among preeclamptic mothers compared to those women who did not have preeclampsia.
"We found that chronic periodontitis was more prevalent in the preeclamptic group by almost 64 percent than the non-preeclamptic group at 36 percent," said Dr. Adolfo Contreras from the School of Dentistry, University of Valle, Cali-Columbia.
"Women in the preeclamptic group had more clinical attachment loss than the healthy women group. Moreover, mothers having preeclampsia showed greater periodontal destruction."
Researchers also found that chronic periodontal disease and the presence of the microorganisms, such as Porphyromonas gingivalis (P.gingivalis);
Tannerella forsythia (T. forsythia); and Eikenella corrodens (E.corrodens) were significantly associated with preeclampsia in pregnant women.
This might mean that periodontal bacterium could find its way into the
bloodstream in patients with periodontal disease. "P. gingivalis has not only been found in the blood circulation but also in atherosclerotic plaques, which has been linked to periodontal disease and cardiovascular disease," explained Contreras.
"The results of this study provide additional evidence that periodontal
infection is linked to preeclampsia; however, further research is needed to support a causal association and its clinical implications," said Kenneth A. Krebs, DMD and AAP president.
"Pregnancy-associated gingivitis is a preventable and easy to treat disease. It is still not known what is the precise mechanisms involved are in the association between periodontal infections and preterm birth. To date, no harmful damaging effect caused by periodontal intervention in pregnant women has been reported."
The study included 130 preeclamptic and 243 non-preeclamptic women between 26 to 36 weeks of pregnancy. A clinical record regarding personal information, marital status, race, education level, number of pregnancies and medical examination was completed for all patients. Preeclampsia was defined as high protein levels in urine (2+ proteinuria), confirmed by at least 0.3 g proteinuria/24 hours and hypertension. Clinical measures of periodontal health were determined in all subjects, including sulcus/probing depth (PD), gingival recession, and periodontal clinical attachment loss (CAL).