Study confirms effectiveness of spray that improves dry mouth caused by antidepressants

Researchers from the University of Granada and the University of Murcia have confirmed the effectiveness of a spray containing 1% malic acid, which seems to greatly improve dry mouth — also known as xerostomy — often caused by antidepressant drugs. Malic acid in a spray form, combined with xylitol and fluorides, stimulates saliva production.

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The research was carried out in a double-blind randomized clinical trial on 70 patients diagnosed with antidepressant-induced xerostomy, split into two groups of 35 patients each. The first group took a sialogogue mouth spray (1% malic acid) for two weeks, while the second group received a placebo. To check the xerostomy both before and after applying both the product and the placebo, the researchers used a specific questionnaire, called the Dry Mouth Questionnaire (DMQ).

Further details from the study are available in ScienceDaily.