As new discoveries emerge from the laboratory, clinical trials are crucial to develop these discoveries into the next generation of products. Successful clinical trials require effective collaboration between the NIDCR, the Food and Drug Administration (FDA), and industry. To promote this interaction, NIDCR and the FDA hosted the second Dental, Oral and Craniofacial Technology Forum, December 11-13, 2001 on the NIH campus. Organized by Drs. Bernard Janicki from the NIDCR and Edward F. Rossomando from the University of Connecticut School of Dental Medicine, and Dr. M. Susan Runner from the FDA, the forum was attended by more than 60 people, including representatives from Federal agencies, industry, professional and scientific societies, advocacy groups, and educational associations.