Seeing the forest for the trees
Jump aboard Dr. Richard Nagelberg's blog for an exciting ride through the ever-changing world of oral-systemic science made understandable. Learn about how biomarkers, bacteria, salivary analysis, and healthspan all fit together in his first post, beginning with a study of the details and a step back to survey the big picture.
The reason this is only now emerging is the ability to detect the very small concentrations of biomarkers in saliva compared to the blood. Biomarkers in saliva are commonly found in nanogram concentrations (one billionth of a gram) or picograms (one trillionth of a gram). The ability to detect these minute quantities is a recent phenomenon, hence the plethora of research using saliva as the testing medium rather than serum. Expectorating saliva is a lot easier and more tolerable compared to a blood draw to obtain a sample.
Another research advance that will modify the manner in which we care for our patients is the detection of bacterial RNA activity, specifically messenger RNA (mRNA). Whereas DNA bacterial analysis can detect the specific microbes that cause an individual patient’s periodontitis, RNA analysis provides information on the cellular events occurring in a patient with periodontitis, and which bacteria are transcribing genes for virulence factors, ultimately causing the clinical manifestations of disease that we see on a daily basis.
Another trend will be more and more chairside salivary detection of bacteria, disease activity, and biomarkers for a variety of diseases and conditions, not limited to the oral cavity. Sooner, rather than later, salivary samples will be obtained to detect biomarkers for head and neck cancer, sleep apnea, dental caries, periodontal disease, and Alzheimer’s disease, among many others. Seems like science fiction, but so did digital x-rays before they were available.
The overarching reason we focus on the details is to increase our patients’ healthspan, trying to match it to their lifespan.
READ DR. NAGELBERG'S NEXT BLOG |The new model of periodontal disease
Richard H. Nagelberg, DDS, has practiced general dentistry in suburban Philadelphia for more than 30 years. He is a speaker, advisory board member, consultant, and key opinion leader for several dental companies and organizations. He lectures on a variety of topics centered on understanding the impact dental professionals have beyond the oral cavity. Contact Dr. Nagelberg at firstname.lastname@example.org.
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