As the human papillomavirus negative (HPV) (-) squamous cell head and neck cancer (SCCHN) is associated with a poor prognosis and decreased response to treatment, one group studied the correlation between protein-based biomarkers related to DNA repair, mitotic regulators and apoptosis in a tissue microarray (TMA) of HPV(-) SCCHN.(4) The researchers concluded that four proteins that are essential in cell replication, cell death, and DNA repair could lead to improved targets for therapy against head and neck squamous cell cancers that are resistant to treatment.(4)
The definitive goal is to understand a tumor's protein signature and underlying biology so that, in the future, researchers can better understand treatments that are likely to be valuable to those with head and neck cancer.References
RELATED | Studies undrescore genetic complexity of head and neck squamous cell cancers
1. Ahrens W, Pohlabeln H, Foraita R, et al. Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: The ARCAGE study. Oral Oncology
. Published online March 28 2014. Quantification of Excision Repair Cross-Complementing Group 1 and Survival in p16-Negative Squamous Cell Head and Neck Cancers. 2. Gandini S, Negri E, Boffetta P, Negri’ M, La Vecchia C, and Boyle P. Mouthwash and Oral Cancer Risk – Quantitative Meta-analysis of Epidemiologic Studies. Annals of Agricultural and Environmental Medicine 2012
, Vol 19, No 2, 173-180. 3. Mehra R, Zhu F, Yang DH, Cai KQ, Weaver J, Singh MK, et al. Quantification of Excision Repair Cross-Complementing Group 1 and Survival in p16-Negative Squamous Cell Head and Neck Cancers. Clin Cancer Res
December 1, 2013 19; 6633-6643. 4. Mehra R, Yang D, Handorf E, et al. Analysis of a protein expression biomarkers in HPV negative SCCHN. AACR Annual Meeting 2014, April 5-9, 2014, San Diego, CA. Abstract Number: 4743. http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=a226e7d9-d3ec-4a9f-ad1e-e766b6ca7473&cKey=afe24196-bf47-4c5e-8012-35515cd2841d&mKey=%7b6FFE1446-A164-476A-92E7-C26446874D93%7d
.More by Maria Perno Goldie:Up in smoke: Tobacco myths persist 50 yearsGenetic techniques and dental care: What is the connection?